However, neither p27 accumulation nor SA\\gal\positive cells were reversed by simultaneous silencing of Cdh1 and 14\3\3 (Figure ?(Number3E,F) - MEK Inhibitors in highly invasive breast cancer cells

However, neither p27 accumulation nor SA\\gal\positive cells were reversed by simultaneous silencing of Cdh1 and 14\3\3 (Figure ?(Number3E,F).3E,F). of cullin\1 (Cul\1) as follows. (a) Neddylated Cul\1 is definitely decreased by 14\3\3 silencing. (b) Blocking neddylation using MLN4924 reproduces senescence phenotypes. (c) Knockdown of CSN5, which functions like a deneddylase, was shown to restore the senescence … Continue reading However, neither p27 accumulation nor SA\\gal\positive cells were reversed by simultaneous silencing of Cdh1 and 14\3\3 (Figure ?(Number3E,F)